Publikationen

2024

• Remodelling of the cardiac extracellular matrix proteome during chronological and pathological ageing.
  Santinha D, Vilaça A, Estronca L, Schüler SC, Bartoli C, De Sandre-Giovannoli A, Figueiredo A, Quaas M, Pompe T, Ori** A, Ferreira** L
  Mol Cell Proteomics 2024, 23(1), 100706 ** co-corresponding authors
  
• Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD.
  Seddighi S, Qi YA, Brown AL, Wilkins OG, Bereda C, Belair C, Zhang YJ, Prudencio M, Keuss MJ, Khandeshi A, Pickles S, Kargbo-Hill SE, Hawrot J, Ramos DM, Yuan H, Roberts J, Sacramento EK, Shah SI, Nalls MA, Colón-Mercado JM, Reyes JF, Ryan VH, Nelson MP, Cook CN, Li Z, Screven L, Kwan JY, Mehta PR, Zanovello M, Hallegger M, Shantaraman A, Ping L, Koike Y, Oskarsson B, Staff NP, Duong DM, Ahmed A, Secrier M, Ule J, Jacobson S, Reich DS, Rohrer JD, Malaspina A, Dickson DW, Glass JD, Ori A, Seyfried NT, Maragkakis M, Petrucelli L, Fratta P, Ward ME
  Sci Transl Med 2024, 16(734), eadg7162
  
• Reducing the metabolic burden of rRNA synthesis promotes healthy longevity in Caenorhabditis elegans.
  Sharifi* S, Chaudhari* P, Martirosyan A, Eberhardt AO, Witt F, Gollowitzer A, Lange L, Woitzat Y, Okoli EM, Li H, Rahnis N, Kirkpatrick J, Werz O, Ori A, Koeberle A, Bierhoff** H, Ermolaeva** M
  Nat Commun 2024, 15(1), 1702 * equal contribution, ** co-corresponding authors
  
• Leiomodin 1 promotes myogenic differentiation by modulating Sirtuin 1
  Späth* E, C.Schüler* S, Heinze I, Dau T, Minetti A, Hofmann M, von Maltzahn** J, Ori** A
  bioRxiv 2024, https://doi.org/10.1101/2024.03. * equal contribution, ** co-corresponding authors
  
• Proteomic profiling reveals CEACAM6 function in driving gallbladder cancer aggressiveness through integrin receptor, PRKCD and AKT/ERK signaling.
  Sugiyanto RN, Metzger C, Inal A, Truckenmueller F, Gür K, Eiteneuer E, Huth T, Fraas A, Heinze I, Kirkpatrick J, Sticht C, Albrecht T, Goeppert B, Poth T, Pusch S, Mehrabi A, Schirmacher P, Ji J, Ori A, Roessler S
  Cell Death Dis 2024, 15(10), 780
  
• SEPTIN10-mediated crosstalk between cytoskeletal networks controls mechanotransduction and oncogenic YAP/TAZ signaling.
  Weiler SME, Bissinger M, Rose F, von Bubnoff F, Lutz T, Ori A, Schirmacher P, Breuhahn K
  Cancer Lett 2024, 584, 216637
  

2023

• Human NMDAR autoantibodies disrupt excitatory-inhibitory balance, leading to hippocampal network hypersynchrony.
  Ceanga M, Rahmati V, Haselmann H, Schmidl L, Hunter D, Brauer AK, Liebscher S, Kreye J, Prüss H, Groc L, Hallermann S, Dalmau J, Ori A, Heckmann M, Geis C
  Cell Rep 2023, 42(10), 113166
  
• Integrated omics approaches to study protein complexes in neuronal differentiation and brain aging
  Di Fraia D
  Dissertation 2023, Jena, Germany
  
• Impaired biogenesis of basic proteins impacts multiple hallmarks of the aging brain
  Di Fraia* D, Marino* A, Ho Lee* J, Kelmer Sacramento E, Baumgart M, Bagnoli S, Tomaz da Silva P, Kumar Sahu A, Siano G, Tiessen M, Terzibasi-Tozzini E, Gagneur J, Frydman** J, Cellerino** A, Ori** A
  bioRxiv 2023, 10.1101/2023.07.20.549210 * equal contribution, ** co-corresponding authors
  
• Impact of Hypermannosylation on the Structure and Functionality of the ER and the Golgi Complex.
  Franzka P, Schüler SC, Kentache T, Storm R, Bock A, Katona I, Weis J, Buder K, Kaether C, Hübner CA
  Biomedicines 2023, 11(1), 146.doi: 10.3390/biomedicines110