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4th German p53 Workshop

Conferences Meetings

The 4th German p53 Workshop will take place in Jena, from Monday, January 13rd, to Tuesday, January 14th organized by Martin Fischer at the Leibniz Institute on Aging - Fritz Lipmann Institute (FLI).

Description

The transcription factor p53 is the arguably best-known tumor suppressor that is mutated in approximately the half of all human cancers and dysregulated in many more. It is the most studied gene and protein with more than 120,000 publications in PubMed. Despite the vast body of literature, much remains to be understood regarding the molecular mechanisms elicited by p53 in different contexts.

Since 2017, the bi-annual German p53 Workshop brings together leading experts in the field working in Germany. We are looking forward to host the "4th German p53 Workshop" at the FLI in Jena.

Speakers

Preliminary Programme

Monday (13 January 2025)

1 pm - Welcome (Martin Fischer, Steve Hoffmann)

1ˢᵗ Session p53 in the DNA Damage Response (Chair: Christine Blattner)

1:15 pm - p53 in the Damage Tolerance of Genome and Epigenome / Ivano Amelio, University of Konstanz

1:45 pm - Influences of p53 and survivin on the shape of cell survival curves after irradiation of colorectal cancer cell lines / Carsten Herskind, Heidelberg University

2:15 pm - Guiding the guardian: regulation of p53 dynamics in individual cells / Alexander Loewer, Technical University of Darmstadt

2:45 pm - Non-canonical role of p53 in DNA damage tolerance pathway usage impacts on breast and ovarian cancer susceptibility / Lisa Wiesmüller and Rebecca Jansche, University of Ulm

3:15 – 4:30 pm - Coffee Break and Posters

2ⁿᵈ Session p53 Regulators and Effectors (Chair: Alexander Loewer)

4:30 pm - A p53-independent role of HIPK2 in DNA double-strand break repair / Thomas Hofmann, University of Mainz

5:00 pm - Regulators and effectors: multiple jobs of MDM2 and MDM4 / Matthias Dobbelstein, University of Göttingen

5:30 pm - p53 and beyond / Christine Blattner, Karlsruhe Institute of Technology

6:00 pm - Role of the p53-inducible microRNA Mir34a in the suppression of colitis-associated colorectal cancer by tumor-associated macrophages / Heiko Hermeking, Ludwig Maximilians University Munich

6:30 - 9 pm - Dinner and Posters

Tuesday (14 January 2025)

3ʳᵈ Session Transcriptional Regulation by p53 (Chair: Ramona Schulz-Heddergott)

8:30 am - The Good or the Bad? – BRCA1 and BRCA2 downregulation by p53, RB, and DREAM / Kurt Engeland, University of Leipzig

9:00 am - Dynamic combinatorial p53 post-translational modifications regulate transcription and cell fates / Dan Lu, Harvard Medical School

9:30 am - The p53 transcriptional program reveals principles of enhancer activity and pioneer function / Martin Fischer, Leibniz Instiute on Aging – Fritz Lipmann Institute (FLI)

10:00 – 11:00 am - Coffee break and Posters

4ᵗʰ Session Mutation and Reactivation of p53 (Chair: Martin Fischer)

11:00 am - DARPins protect p53 from HPV E6-induced degradation / Volker Dötsch, Goethe University Frankfurt

11:30 am - Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutations / Julianne Funk, Philipps University Marburg

12:00 am - Stabilized p53 GOF mutants: Regulators of cancer progression and invasion / Ramona Schulz-Heddergott, University of Göttingen

12:30 am - Targeting the p53 mutome for cancer therapy: small-molecule stabilizers and DARPins / Andreas Joerger, Goethe University Frankfurt

1 pm - Concluding Remarks
 

Venue

Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)
Beutenbergstr. 11, 07745 Jena, Seminar Room ,”Nucleus”

Contact & Registration

Martin.Fischer@~@leibniz-fli.de

Deadline: November 30, 2024
Registration cost: 100 €
Payment information will be sent separately.

Registration closed 

Recommended Hotel

Dorint Hotel Esplanade Jena, limited number of rooms with reduced price with the code "p53Workshop".

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