Publikationen

2021

• Extensive remodeling of the extracellular matrix during aging contributes to age-dependent impairments of muscle stem cell functionality.
  Schüler SC, Kirkpatrick* JM, Schmidt* M, Santinha D, Koch P, Di Sanzo S, Cirri E, Hemberg M, Ori** A, von Maltzahn** J
  Cell Rep 2021, 35(10), 109223 * equal contribution, ** co-senior authors
  
• HAT cofactor TRRAP modulates microtubule dynamics via SP1 signaling to prevent neurodegeneration.
  Tapias* A, Lázaro* D, Yin* BK, Rasa SMM, Krepelova A, Kelmer Sacramento E, Grigaravicius P, Koch P, Kirkpatrick J, Ori A, Neri F, Wang ZQ
  Elife 2021, 10, e61531 * equal contribution
  

2020

• Spatially resolved analysis of FFPE tissue proteomes by quantitative mass spectrometry.
  Buczak K, Kirkpatrick JM, Truckenmueller F, Santinha D, Ferreira L, Roessler S, Singer S, Beck** M, Ori** A
  Nat Protoc 2020, 15(9), 2956-79 ** co-corresponding authors
  
• Loss of metabolic plasticity underlies metformin toxicity in aged Caenorhabditis elegans.
  Espada* L, Dakhovnik* A, Chaudhari* P, Martirosyan A, Miek L, Poliezhaieva T, Schaub Y, Nair A, Döring N, Rahnis N, Werz O, Koeberle A, Kirkpatrick J, Ori A, Ermolaeva MA
  Nat Metab 2020, 2(11), 1316-31 * equal contribution
  
• Region-specific effects of aging on the small intestinal epithelium and the influence of dietary restriction
  Gebert N
  Dissertation 2020, Jena, Germany
  
• Region-Specific Proteome Changes of the Intestinal Epithelium during Aging and Dietary Restriction.
  Gebert N, Cheng CW, Kirkpatrick JM, Di Fraia D, Yun J, Schädel P, Pace S, Garside GB, Werz O, Rudolph KL, Jasper H, Yilmaz ÖH, Ori A
  Cell Rep 2020, 31(4), 107565
  
• Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation.
  Kelmer Sacramento* E, Kirkpatrick* JM, Mazzetto* M, Baumgart M, Bartolome A, Di Sanzo S, Caterino C, Sanguanini M, Papaevgeniou N, Lefaki M, Childs D, Bagnoli S, Terzibasi Tozzini E, Di Fraia D, Romanov N, Sudmant PH, Huber W, Chondrogianni N, Vendruscolo M, Cellerino** A, Ori** A
  Mol Syst Biol 2020, 16(6), e9596 * equal contribution, ** co-corresponding authors
  
• The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
  Liu H, Ding J, Köhnlein K, Urban N, Ori A, Villavicencio-Lorini P, Walentek P, Klotz LO, Hollemann T, Pfirrmann T
  Autophagy 2020, 16(9), 1618-34
  
• Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13.
  Pitrez PR, Estronca L, Monteiro LM, Colell G, Vazão H, Santinha D, Harhouri K, Thornton D, Navarro C, Egesipe AL, Carvalho T, Dos Santos RL, Lévy N, Smith JC, de Magalhães JP, Ori A, Bernardo A, De Sandre-Giovannoli A, Nissan X, Rosell A, Ferreira L
  Nat Commun 2020, 11(1), 4110
  
• Proteomic analyses of muscle stem cells and their niche reveal novel factors affecting regeneration of skeletal muscle during aging
  Schüler SC
  Dissertation 2020, Jena, Germany