Dr. Anna Poetsch, a group leader at TU Dresden, will present her latest research on the use of DNA language models to understand sequence preferences for DNA damage and repair. Dr. Poetsch completed her PhD at the German Cancer Research Institute (DKFZ) and spent her postdoctoral time at the Francis Crick Institute, with a placement at the Okinawa Institute of Science and Technology (OIST). Her undergraduate training includes a Bachelor's and Master's degree in Life Sciences from the University of Konstanz, along with experience at the Japanese National Cancer Center Research Institute and ALTANA Pharma AG.
In her talk, Dr. Poetsch will explore how DNA damage and repair are influenced by the underlying epigenome, transcription, and replication processes. She will discuss her innovative use of models such as GROVER (Genome Rules Obtained via Extracted Representations) and EAGLE-MUT (Efficient Analysis with a Genome-wide LSTM to Evaluate per-nucleotide MUTation susceptibility) to investigate the stability encoded in DNA and the implications for somatic genome evolution, aging, and cancer.
| Talk: | Using DNA language models to understand sequence preferences for DNA damage and repair |
| Speaker: | Anna R. Poetsch Technische Universität Dresden, Center for Molecular and Cellular Bioengineering (CMCB) |
| Date: | Tuesday, November 19, 2024 at 3 pm |
| Location: | Seminar room „Nucleus“, FLI 1, Beutenbergstraße 11, Jena |
| Host: | Alena van Bömmel |
The seminar will take place in person.
