Publications

2020

• Systematic elucidation of neuron-astrocyte interaction in models of amyotrophic lateral sclerosis using multi-modal integrated bioinformatics workflow.
  Mishra V, Re DB, Le Verche V, Alvarez MJ, Vasciaveo A, Jacquier A, Doulias PT, Greco TM, Nizzardo M, Papadimitriou D, Nagata T, Rinchetti P, Perez-Torres EJ, Politi KA, Ikiz B, Clare K, Than ME, Corti S, Ischiropoulos H, Lotti F, Califano A, Przedborski S
  Nat Commun 2020, 11(1), 5579
  

2019

• Design, synthesis and characterization of new macrocyclic inhibitors of the proprotein convertase furin.
  Lam van TV, Ivanova T, Hardes K, Heindl MR, Morty RE, Böttcher-Friebertshäuser E, Lindberg I, Than ME, Dahms SO, Steinmetzer T
  ChemMedChem 2019, 14(6), 673-85
  

2018

• X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket.
  Dahms SO, Hardes K, Steinmetzer T, Than ME
  Biochemistry 2018, 57(6), 925-34
  

2017

• Structural Studies Revealed Active Site Distortions of Human Furin by a Small Molecule Inhibitor.
  Dahms SO, Jiao** GS, Than** ME
  ACS Chem Biol 2017, 12(5), 1211-6 ** co-corresponding authors
  
• Optimization of Substrate-Analogue Furin Inhibitors.
  Ivanova T, Hardes K, Kallis S, Dahms SO, Than ME, Künzel S, Böttcher-Friebertshäuser E, Lindberg I, Jiao GS, Bartenschlager R, Steinmetzer T
  ChemMedChem 2017, 12(23), 1953-68
  

2016

• Identification of inhibitors of the transmembrane protease FlaK of Methanococcus maripaludis.
  Coburger I, Schaub Y, Roeser D, Hardes K, Maeder P, Klee N, Steinmetzer T, Imhof D, Diederich WE, Than ME
  Microbiologyopen 2016, 5(4), 637-46
  
• The structure of a furin-antibody complex explains non-competitive inhibition by steric exclusion of substrate conformers.
  Dahms SO, Creemers JWM, Schaub Y, Bourenkov GP, Zögg T, Brandstetter H, Than ME
  Sci Rep 2016, 6, 34303.doi:10.1038/srep303
  
• Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism.
  Dahms* SO, Arciniega* M, Steinmetzer T, Huber** R, Than** ME
  Proc Natl Acad Sci U S A 2016, 113(40), 11196-201 * equal contribution, ** co-corresponding authors
  

2015

• Struktur und Funktion des Amyloid-Vorläuferproteins (APP) und seiner Interaktionspartner
  Coburger I
  Dissertation 2015, Jena, Germany
  
• Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes.
  Dahms SO, Mayer MC, Roeser D, Multhaup G, Than ME
  Acta Crystallogr D Biol Crystallogr 2015, 71(Pt 3), 494-504