Kirstein Research Group
Selected Publications
- Identification of a HTT-specific binding motif in DNAJB1 essential for suppression and disaggregation of HTT.
Ayala Mariscal SM, Pigazzini ML, Richter Y, Özel M, Grothaus IL, Protze J, Ziege K, Kulke M, ElBediwi M, Vermaas JV, Colombi Ciacchi L, Köppen S, Liu F, Kirstein J
Nat Commun 2022, 13(1), 4692 - An Expanded Polyproline Domain Maintains Mutant Huntingtin Soluble in vivo and During Aging.
Pigazzini ML, Lawrenz M, Margineanu A, Kaminski Schierle GS, Kirstein J
Front Mol Neurosci 2021, 14, 721749 - Novel amyloid-beta pathology C. elegans model reveals distinct neurons as seeds of pathogenicity.
Gallrein C, Iburg M, Michelberger T, Koçak A, Puchkov D, Liu F, Ayala Mariscal SM, Nayak T, Kaminski Schierle GS, Kirstein J
Prog Neurobiol 2021, 198, 101907 - The noncanonical small heat shock protein HSP-17 from Caenorhabditis elegans is a selective protein aggregase.
Iburg M, Puchkov D, Rosas-Brugada IU, Bergemann L, Rieprecht U, Kirstein J
J Biol Chem 2020, 295(10), 3064 - ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans.
Kreis P, Gallrein C, Rojas-Puente E, Mack TGA, Kroon C, Dinkel V, Willmes C, Murk K, Tom-Dieck S, Schuman EM, Kirstein** J, Eickholt** BJ
Nat Commun 2019, 10(1), 486 ** co-corresponding authors - Crosstalk Between Chaperone-Mediated Protein Disaggregation and Proteolytic Pathways in Aging and Disease.
Feleciano DR, Juenemann K, Iburg M, Brás IC, Holmberg CI, Kirstein J
Front Aging Neurosci 2019, 11, 9 - Complete suppression of Htt fibrilization and disaggregation of Htt fibrils by a trimeric chaperone complex.
Scior A, Buntru A, Arnsburg K, Ast A, Iburg M, Juenemann K, Pigazzini ML, Mlody B, Puchkov D, Priller J, Wanker EE, Prigione A, Kirstein J
EMBO J 2018, 37(2), 282 - In vivo properties of the disaggregase function of J-proteins and Hsc70 in Caenorhabditis elegans stress and aging.
Kirstein J, Arnsburg K, Scior A, Szlachcic A, Guilbride DL, Morimoto RI, Bukau B, Nillegoda NB
Aging Cell 2017, 16(6), 1414 - Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments.
Kirstein** J, Morito D, Kakihana T, Sugihara M, Minnen A, Hipp MS, Nussbaum-Krammer C, Kasturi P, Hartl** FU, Nagata** K, Morimoto** RI
EMBO J 2015, 34(18), 2334 ** co-corresponding authors - Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation.
Nillegoda NB, Kirstein J, Szlachcic A, Berynskyy M, Stank A, Stengel F, Arnsburg K, Gao X, Scior A, Aebersold R, Guilbride DL, Wade RC, Morimoto RI, Mayer MP, Bukau B
Nature 2015, 524(7564), 247
