Current Projects

MicroRNAs and Aging

To understand the regulation of microRNAs during aging, next-generation sequencing is applied. These microRNAs are part of a network that is centered on the antagonistic actions of MYC and TP53 and is conserved in mammals and humans. Some of these microRNAs, like miR-15a and the miR cluster 17~92 are specifically expressed and regulated in the neuronal stem cells in vivo. We will now proceed with functional tests of the activity of these genes.

Aging of Neuronal Stem Cells

As a consequence of aging, the neuronal stem cells of N. furzeri greatly reduce their proliferative capacity. Using next-generation sequencing, we identified novel genes that are expressed in the neuronal stem cells and are regulated similarly in N. furzeri and humans. In addition, we revealed that brain aging is associated to prominent epigenetic remodeling and activation of the polycomb complex. Our research will then focus on in vivo manipulation of gene expression to investigate how these genes regulate neuronal stem cell function.

Effects of Mild Stress (Hormesis)

It is known that low-dosage stressors can induce positive effects on cellular function by inducing a protective response. Using N. furzeri, we are currently investigating how mild stress can contrast the effects of aging and promote longevity.