Project Biochemistry (until 2023)

Publications

Compromised CDK12 activity causes dependency on the high activity of O-GlcNAc transferase.
Pallasaho S, Gondane A, Kutz J, Liang J, Yalala S, Duveau DY, Pospiech H, Thomas CJ, Loda M, Itkonen HM
Glycobiology 2024 (epub ahead of print)

Targeting cellular pathways in hyper- and ultramutated cancer cells with exonuclease-defective DNA polymerase epsilon
Borges G
Dissertation 2023, Jena, Germany
ABRAXAS1 orchestrates BRCA1 activities to counter genome destabilizing repair pathways-lessons from breast cancer patients.
Sachsenweger J, Jansche R, Merk T, Heitmeir B, Deniz M, Faust U, Roggia C, Tzschach A, Schroeder C, Riess A, Pospiech H, Peltoketo H, Pylkäs K, Winqvist R, Wiesmüller L
Cell Death Dis 2023, 14(5), 328

Partial Reduction in BRCA1 Gene Dose Modulates DNA Replication Stress Level and Thereby Contributes to Sensitivity or Resistance.
Classen S, Rahlf E, Jungwirth J, Albers N, Hebestreit LP, Zielinski A, Poole L, Groth M, Koch P, Liehr T, Kankel S, Cordes N, Petersen C, Rothkamm K, Pospiech** H, Borgmann** K
Int J Mol Sci 2022, 23(21) ** co-corresponding authors
Charakterisierung des potentiellen DNA-Replikationsfaktors PN70
Kutz J
Dissertation 2022, Jena, Germany