Paul G. Allen Family Foundation
PRO-Watch: an approach to monitor protein lifespan in aging worms
The project aims to develop a dual-color fluorescent reporter called PRO-Watch to monitor protein lifespan in living organisms, focusing on the nematode Caenorhabditis elegans. By studying muscle proteins, particularly myosin, we seek to understand the correlation between protein and organism lifespans, investigate age-dependent myopathies, and explore the impact of protein folding, incorporation into myofilaments, and degradation. Using PRO-Watch technology, we will analyze myosin mutants to gain insights into protein aging processes and potential health implications. Additionally, the platform will be utilized to screen for compounds and genetic factors influencing protein lifespan regulation.
Cooperating partners
Leibniz Institute on Aging – Fritz Lipmann Institute (FLI)
Research Institute of Molecular Pathology (IMP), Vienna
