Chan Zuckerberg Initiative – Collaborative Pairs Pilot Project Awards (Cycle 1) (Phase 2)
TDP-43 Mislocalization in Aging and Neurodegeneration
The collaborative project aims to identify genetic and age-dependent factors contributing to TDP-43 mislocalization, a key feature of neurodegenerative diseases. By conducting experiments in iPSC neurons, killifish, and post-mortem human cortex, we will uncover molecular mechanisms underlying TDP-43 mislocalization in aging and disease contexts. The project seeks to elucidate convergent pathways regulating TDP-43 biology and explore potential therapeutic targets for ALS and age-related neurodegenerative disorders through functional genomic screens and multi-omic investigations. The goal is to understand the causes of TDP-43 mislocalization and potentially develop interventions to prevent or delay age-related phenotypes associated with neurodegeneration.
Cooperating partners
Leibniz Institute on Aging – Fritz Lipmann Institute (FLI)
National Institutes of Health, Bethesda, MD, USA
New York Genome Center, NY, USA
European Molecular Biology Laboratory, Heidelberg & Stanford University, CA, USA
![Logo Chan Zuckerberg Initiative Logo Chan Zuckerberg Initiative](https://www.leibniz-fli.de/fileadmin/_processed_/4/e/csm_Chan_Zuckerberg_Initiative-Logo.wine_d7d6c328fd.jpg)
Contact
![Alessandro Ori Portrait of Alessandro Ori](https://www.leibniz-fli.de/fileadmin/_processed_/e/d/csm_AlessandroOri_cb8a11f4b6.jpg)
Alessandro Ori
Partner
alessandro.ori@~@leibniz-fli.de
Contact
![Prof. Dr. Dario Riccardo Valenzano Portrait of Prof. Dr. Dario Riccardo Valenzano](https://www.leibniz-fli.de/fileadmin/_processed_/1/7/csm_DSC08120_Favorit_2_e208257059.jpg)
Dario Riccardo Valenzano
Partner
+49 3641 65-6280
dario.valenzano@leibniz-fli.de
More information: