Chan Zuckerberg Initiative – Collaborative Pairs Pilot Project Awards (Cycle 1) (Phase 2)

The collaborative project aims to identify genetic and age-dependent factors contributing to TDP-43 mislocalization, a key feature of neurodegenerative diseases. By conducting experiments in iPSC neurons, killifish, and post-mortem human cortex, we will uncover molecular mechanisms underlying TDP-43 mislocalization in aging and disease contexts. The project seeks to elucidate convergent pathways regulating TDP-43 biology and explore potential therapeutic targets for ALS and age-related neurodegenerative disorders through functional genomic screens and multi-omic investigations. The goal is to understand the causes of TDP-43 mislocalization and potentially develop interventions to prevent or delay age-related phenotypes associated with neurodegeneration.

Cooperating partners

Leibniz Institute on Aging – Fritz Lipmann Institute (FLI)

• Alessandro Ori
• Dario Riccardo Valenzano

National Institutes of Health, Bethesda, MD, USA

• Michael Ward

New York Genome Center, NY, USA

• Hemali Phatnani

European Molecular Biology Laboratory, Heidelberg & Stanford University, CA, USA

• Lars Steinmetz