Core Facilites and Core Services

At the beginning of 2016, a “core” structure was put into effect that organized facility and service units as independent organizational entities from FLI’s research groups. A number of technology platforms (e.g. sequencing, mass spectrometry) grew out of individual methodological requirements for single research groups in the last years but developed into semiautonomous substructures. As consequence of re-focused research activities and the concomitant advent of new research groups at FLI, those units increasingly had to serve many FLI groups and collaborative research efforts in the Jena research area.

To accommodate this development and to increase efficiency as well as transparency for users, facility personnel and for administrative processes, it came natural to re-organize such activities into independent units as “FLI Core Facilities and Services” and to phase out infrastructures considered non-essential for FLI’s research focus (X-ray crystallography and NMR spectroscopy).

FLI’s Core Facilities (CF) are managed by a CF Manager and are each scientifically guided in their activities and development by an FLI Group Leader, as Scientific Supervisor. The animal facilities comprising fish, mouse and transgenesis are run separately, as they involve a more complex organizational structure. Basic Core Services (CS) are directly led by the Head of Core (HC), who in turn is supported by individual CS Managers.

All facilities and services, including animal facilities, have a valuable contribution to FLI’s research articles; e.g. from 2016–2018, to 54% of all peer reviewed research publications.

Overview Core Facilities and Core Services at FLI.

Publications

(since 2016)

2018

Multiple roots of fruiting body formation in Amoebozoa.
Hillmann F, Forbes G, Novohradská S, Ferling I, Riege K, Groth M, Westermann M, Marz M, Spaller T, Winckler T, Schaap P, Glöckner G
Genome Biol Evol 2018, 10(2), 591-606
Multimodal Light Microscopy Approaches to Reveal Structural and Functional Properties of Promyelocytic Leukemia Nuclear Bodies.
Hoischen C, Monajembashi S, Weisshart K, Hemmerich P
Front Oncol 2018, 8, 125
CENP-C/H/I/K/M/T/W/N/L and hMis12 but not CENP-S/X participate in complex formation in the nucleoplasm of living human interphase cells outside centromeres.
Hoischen* C, Yavas* S, Wohland T, Diekmann S
PLoS One 2018, 13(3), e0192572 * equal contribution
3D Network exploration and visualisation for lifespan data.
Hühne* R, Kessler* V, Fürstberger* A, Kühlwein S, Platzer M, Sühnel J, Lausser L, Kestler HA
BMC Bioinformatics 2018, 19(1), 390 * equal contribution
Synthesis and biochemical evaluation of two novel N-hydroxyalkylated cyclosporin A analogs.
Kahlert V, Prell E, Ohlenschläger O, Melesina J, Schumann M, Lücke C, Fischer G, Malešević M
Org Biomol Chem 2018, 16(23), 4338-49
Glucocorticoid receptor in stromal cells is essential for glucocorticoid-mediated suppression of inflammation in arthritis.
Koenen M, Culemann S, Vettorazzi S, Caratti G, Frappart L, Baum W, Krönke G, Baschant U, Tuckermann JP
Ann Rheum Dis 2018, 77(11), 1610-8
Heme interaction of the intrinsically disordered N-terminal peptide segment of human cystathionine-β-synthase.
Kumar A, Wißbrock A, Goradia N, Bellstedt P, Ramachandran R, Imhof D, Ohlenschläger O
Sci Rep 2018, 8(1), 2474
Deletion of Menin in craniofacial osteogenic cells in mice elicits development of mandibular ossifying fibroma.
Lee S, Liu P, Teinturier R, Jakob J, Tschaffon M, Tasdogan A, Wittig R, Hoeller S, Baumhoer D, Frappart L, Vettorazzi S, Bertolino P, Zhang C, Tuckermann J
Oncogene 2018, 37(5), 616-26
Conformational Plasticity in Broadly Neutralizing HIV-1 Antibodies Triggers Polyreactivity.
Prigent J, Jarossay A, Planchais C, Eden C, Dufloo J, Kök A, Lorin V, Vratskikh O, Couderc T, Bruel T, Schwartz O, Seaman MS, Ohlenschläger** O, Dimitrov** JD, Mouquet** H
Cell Rep 2018, 23(9), 2568-81 ** co-corresponding authors
Impairing L-Threonine Catabolism Promotes Healthspan through Methylglyoxal-Mediated Proteohormesis.
Ravichandran M, Priebe S, Grigolon G, Rozanov L, Groth M, Laube B, Guthke R, Platzer M, Zarse K, Ristow M
Cell Metab 2018, 27(4), 914-25