The Sherman lab has found that the glycosaminoglycan hyaluronan (HA) accumulates throughout the brain with normative aging, a process that is accelerated in cases of age-related vascular brain injury and dementia.
Dysregulated HA signaling through the CD44 transmembrane HA receptor leads to cognitive dysfunction, altered neurogenesis, and a persistent neuroinflammatory response involving changes in brain vascular endothelial cells.
The talk will highlight how each targeted approaches to treating age-related cognitive decline can be implemented with respect to both of these processes.
is Professor at the , Beaverton, USA. The Sherman lab focuses, among other things, on how neuronal cell differentiation is regulated and how these cells can be influenced to promote recovery from neurodegenerative diseases.
| Title of Talk: | Contributions of hyaluronan catabolism to cognitive dysfunction in aging and neuroinflammatory diseases |
| When: | Thursday, August 24, 2023, 3:00 pm |
| Where: | Seminar room “Nucleus”, main building (FLI 1), Beutenbergstraße 11, Jena |
| Host: | Helen Morrison (Group leader: Nerve Regeneration) |
The colloquium will be a hybrid event. Details for accessing the session will be provided before the colloquium takes place. For external guests: Please contact Ivonne.Roeppnack-Jahnke@~@leibniz-fli.de for details.
