Human Frontier Science Program

Nucleotides are essential building blocks of DNA and RNA, but their modified forms also play crucial roles in gene regulation and biological processes, such as DNA repair and enhancing chemotherapy effectiveness. Despite their significance, our understanding of these modified nucleotides is still limited. This project aims to systematically explore the diversity and functions of modified nucleotides across species using advanced chemistry, computational modeling, and cellular biology techniques. We will also investigate the enzymes that modify or detoxify harmful nucleotides, examining their evolution and roles in various organisms. By tracing the origins and interactions of these nucleotides, we hope to unlock new scientific insights, advance medical therapies, and enhance our understanding of evolutionary biology and the molecular interactions that shape life on Earth.

Cooperating Partners

Leibniz Institute on Aging – Fritz Lipmann Institute (FLI)
Clara Correia-Melo

University College London
Kasper Fugger

ETH Zurich
Pedro Beltrao