Former Research Group - Große

Publications

Toxic effects of zinc ions on kinesin - Potential molecular cause of impaired intracellular transport.
Böhm KJ
Toxicol Lett 2017, 268, 58-62
N-Heterocyclic (4-Phenylpiperazin-1-yl)methanones Derived from Phenoxazine and Phenothiazine as Highly Potent Inhibitors of Tubulin Polymerization.
Prinz H, Ridder AK, Vogel K, Böhm KJ, Ivanov I, Ghasemi J, Aghaee E, Müller K:
J Med Chem 2017, 60(2), 749-66
Cdc45-induced loading of human RPA onto single-stranded DNA.
Szambowska A, Tessmer I, Prus P, Schlott B, Pospiech H, Grosse F
Nucleic Acids Res 2017, 45(6), 3217-30

S100A11 plays a role in homologous recombination and genome maintenance by influencing the persistence of RAD51 in DNA repair foci.
Foertsch F, Szambowska A, Weise A, Zielinski A, Schlott B, Kraft F, Mrasek K, Borgmann K, Pospiech** H, Grosse F, Melle** C
Cell Cycle 2016, 15(20), 2766-79 ** co-corresponding authors
DNA damage tolerance pathway involving DNA polymerase ι and the tumor suppressor p53 regulates DNA replication fork progression.
Hampp S, Kiessling T, Buechle K, Mansilla SF, Thomale J, Rall M, Ahn J, Pospiech H, Gottifredi V, Wiesmüller L
Proc Natl Acad Sci U S A 2016, 113(30), E4311-9
Human DNA polymerase α interacts with mismatch repair proteins MSH2 and MSH6.
Itkonen HM, Kantelinen J, Vaara M, Parkkinen S, Schlott B, Grosse F, Nyström M, Syväoja JE, Pospiech H
FEBS Lett 2016, 590(23), 4233-41
Heterozygous PALB2 c.1592delT mutation channels DNA double-strand break repair into error-prone pathways in breast cancer patients.
Obermeier K, Sachsenweger J, Friedl TWP, Pospiech H, Winqvist R, Wiesmüller L
Oncogene 2016, 35(29), 3796-806

The CENP-T C-Terminus Is Exclusively Proximal to H3.1 and not to H3.2 or H3.3.
Abendroth C, Hofmeister A, Hake SB, Kamweru PK, Miess E, Dornblut C, Küffner I, Deng W, Leonhardt H, Orthaus S, Hoischen C, Diekmann S
Int J Mol Sci 2015, 16(3), 5839-63
Elevated copper ion levels as potential cause of impaired kinesin-dependent transport processes.
Böhm KJ
Arch Toxicol 2015, 89(4), 565-72
Aluminium-induced kinesin inactivation as potential molecular cause of impairment of neuronal transport processes.
Böhm KJ, Shabanpour M, Kalchishkova N
Chem Res Toxicol 2015, 28(6), 1275-81