Project Biochemistry (until 2023)

Publications

Cdc45 is limiting for replication initiation in humans.
Köhler C, Koalick D, Fabricius A, Parplys AC, Borgmann K, Pospiech** H, Grosse** F
Cell Cycle 2016, 15(7), 974-85 ** co-senior authors
High-Content Microscopy Analysis of Subcellular Structures: Assay Development and Application to Focal Adhesion Quantification.
Kroll* T, Schmidt* D, Schwanitz G, Ahmad M, Hamann J, Schlosser C, Lin YC, Böhm KJ, Tuckermann J, Ploubidou A
Curr Protoc Cytom 2016, 77, 12.43.1-12.43.44 * equal contribution
Heterozygous PALB2 c.1592delT mutation channels DNA double-strand break repair into error-prone pathways in breast cancer patients.
Obermeier K, Sachsenweger J, Friedl TWP, Pospiech H, Winqvist R, Wiesmüller L
Oncogene 2016, 35(29), 3796-806
TSC loss distorts DNA replication programme and sensitises cells to genotoxic stress.
Pai GM, Zielinski A, Koalick D, Ludwig K, Wang ZQ, Borgmann K, Pospiech H, Rubio I
Oncotarget 2016, 7(51), 85365-80
Assembly of the Cdc45-Mcm2-7-GINS Complex, the Replication Helicase
Pospiech H, Szambowska A
In: The Initiation of DNA Replication in Eukaryotes (edited by Daniel Kaplan) 2016, 393-409, Springer International