Former Research Group - Than (until 2015)

Publications

Heparin-induzierte Dimerisierung des Amyloid Vorläufer Proteins APP und biochemische Charakterisierung der γ-Sekretase Untereinheit Nikastrin
Höfgen S
Dissertation 2014, Jena, Germany
Novel Zinc-binding Site in the E2 Domain Regulates Amyloid Precursor-like Protein 1 (APLP1) Oligomerization.
Mayer MC, Kaden D, Schauenburg L, Hancock MA, Voigt P, Roeser D, Barucker C, Than ME, Schaefer M, Multhaup G
J Biol Chem 2014, 289(27), 19019-30
Crystal structure of the antimicrobial peptidase lysostaphin from Staphylococcus simulans.
Sabala I, Jagielska E, Bardelang PT, Czapinska H, Dahms SO, Sharpe JA, James R, Than ME, Thomas NR, Bochtler M
FEBS J 2014, 281(18), 4112-22

Analysis of the overall structure of the multi-domain amyloid precursor protein (APP).
Coburger I, Dahms SO, Roeser D, Gührs KH, Hortschansky P, Than ME
PLoS One 2013, 8(12), e81926
Localization and orientation of heavy-atom cluster compounds in protein crystals using molecular replacement.
Dahms SO, Kuester M, Streb C, Roth C, Sträter N, Than ME
Acta Crystallogr D Biol Crystallogr 2013, 69(Pt 2), 284-97
Regulation of Son of sevenless by the membrane-actin linker protein ezrin.
Geißler KJ, Jung MJ, Riecken LB, Sperka T, Cui Y, Schacke S, Merkel U, Markwart R, Rubio I, Than ME, Breithaupt C, Peuker S, Seifert R, Kaupp UB, Herrlich P, Morrison H
Proc Natl Acad Sci U S A 2013, 110(51), 20587-92
The amyloid precursor protein (APP) does not have a ferroxidase site in its E2 domain.
Honarmand Ebrahimi K, Dienemann C, Hoefgen S, Than ME, Hagedoorn PL, Hagen WR
PLoS One 2013, 8(8), e72177

Heterozygous mutations causing partial prohormone convertase 1 deficiency contribute to human obesity.
Creemers JWM, Choquet H, Stijnen P, Vatin V, Pigeyre M, Beckers S, Meulemans S, Than ME, Yengo L, Tauber M, Balkau B, Elliott P, Jarvelin MR, Van Hul W, Van Gaal L, Horber F, Pattou F, Froguel P, Meyre D
Diabetes 2012, 61(2), 383-90
Strukturelle und biochemische Charakterisierung des extrazellulären Bereichs des Amyloid-Vorläuferproteins (APP)
Dahms SO
Dissertation 2012, Jena, Germany
Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain.
Dahms SO, Könnig I, Roeser D, Gührs KH, Mayer MC, Kaden D, Multhaup G, Than ME
J Mol Biol 2012, 416(3), 438-52