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Deriving life extension strategies from the intestinal microbiome of human centenarians
Chaudhari PS
Dissertation 2022, Jena, Germany
Novel biochemical, structural, and systems insights into inflammatory signaling revealed by contextual interaction proteomics.
Ciuffa R, Uliana F, Mannion J, Mehnert M, Tenev T, Marulli C, Satanowski A, Keller LML, Rodilla Ramírez PN, Ori A, Gstaiger M, Meier P, Aebersold R
Proc Natl Acad Sci U S A 2022, 119(40), e2117175119
Partial Reduction in BRCA1 Gene Dose Modulates DNA Replication Stress Level and Thereby Contributes to Sensitivity or Resistance.
Classen S, Rahlf E, Jungwirth J, Albers N, Hebestreit LP, Zielinski A, Poole L, Groth M, Koch P, Liehr T, Kankel S, Cordes N, Petersen C, Rothkamm K, Pospiech** H, Borgmann** K
Int J Mol Sci 2022, 23(21) ** co-corresponding authors
p53-mediated AKT and mTOR inhibition requires RFX7 and DDIT4 and depends on nutrient abundance.
Coronel* L, Häckes* D, Schwab* K, Riege K, Hoffmann** S, Fischer** M
Oncogene 2022, 41(7), 1063-9 * equal contribution, ** co-corresponding authors
Combined Activity of the Redox-Modulating Compound Setanaxib (GKT137831) with Cytotoxic Agents in the Killing of Acute Myeloid Leukemia Cells.
Demircan MB, Mgbecheta PC, Kresinsky A, Schnoeder TM, Schröder K, Heidel FH, Böhmer FD
Antioxidants (Basel) 2022, 11(3)
Context-specific effects of NOX4 inactivation in acute myeloid leukemia (AML).
Demircan MB, Schnoeder TM, Mgbecheta PC, Schröder K, Böhmer FD, Heidel FH
J Cancer Res Clin Oncol 2022, 148(8), 1983-90
Conserved exchange of paralog proteins during neuronal differentiation.
Di Fraia D, Anitei M, Mackmull MT, Parca L, Behrendt L, Andres-Pons A, Gilmour D, Helmer Citterich M, Kaether C, Beck M, Ori A
Life Sci Alliance 2022, 5(6)
The Essential DNA Damage Response Complex MRN Is Dispensable for the Survival and Function of Purkinje Neurons.
Ding* M, Qing* X, Zhang G, Baade-Büttner C, Gruber R, Lu H, Ferguson DO, Geis C, Wang** ZQ, Zhou** ZW
Front Aging Neurosci 2022, 13, 786199 * equal contribution, ** co-senior authors
Metabolic determination of cell fate through selective inheritance of mitochondria.
Döhla J, Kuuluvainen E, Gebert N, Amaral A, Englund JI, Gopalakrishnan S, Konovalova S, Nieminen AI, Salminen ES, Torregrosa Muñumer R, Ahlqvist K, Yang Y, Bui H, Otonkoski T, Käkelä R, Hietakangas V, Tyynismaa H, Ori A, Katajisto P
Nat Cell Biol 2022, 24(2), 148-54
Planning preclinical confirmatory multicenter trials to strengthen translation from basic to clinical research – a multi-stakeholder workshop report
Drude NI, Martinez-Gamboa L, Danziger M, Collazo A, Kniffert S, Wiebach J, Nilsonne G, Konietschke F, Piper SK, Pawel S, Micheloud C, Held L, Frommlet F, Segelcke D, Pogatzki-Zahn EM, Voelkl B, Friede T, Brunner E, Dempfle A, Haller B, Jung MJ, Riecken LB, Kuhn HG, Tenbusch M, Serna Higuita LM, Remarque EJ, Grüninger-Egli SL, Manske K, Kobold S, Rivalan M, Wedekind L, Wilcke JC, Boulesteix AL, Meinhardt MW, Spanagel R, Hettmer S, von Lüttichau I, Regina C, Dirnagl U, Toelch U
Translational Medicine Communications 2022, 7(24), doi 10.1186/s41231-022-00130-8