Publications

2014

• Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features.
  Lessel D, Vaz B, Halder S, Lockhart PJ, Marinovic-Terzic I, Lopez-Mosqueda J, Philipp M, Sim JCH, Smith KR, Oehler J, Cabrera E, Freire R, Pope K, Nahid A, Norris F, Leventer RJ, Delatycki MB, Barbi G, von Ameln S, Högel J, Degoricija M, Fertig R, Burkhalter MD, Hofmann K, Thiele H, Altmüller J, Nürnberg G, Nürnberg P, Bahlo M, Martin GM, Aalfs CM, Oshima J, Terzic J, Amor DJ, Dikic I, Ramadan K, Kubisch C
  Nat Genet 2014, 11, 1239-44
  
• p21 promotes sustained liver regeneration and hepatocarcinogenesis in chronic cholestatic liver injury.
  Marhenke S, Buitrago-Molina LE, Endig J, Orlik J, Schweitzer N, Klett S, Longerich T, Geffers R, Sánchez Muñoz A, Dorrell C, Katz SF, Lechel A, Weng H, Krech T, Lehmann U, Dooley S, Rudolph KL, Manns MP, Vogel A
  Gut 2014, 63(9), 1501-12
  
• Glucose substitution prolongs maintenance of energy homeostasis and lifespan of telomere dysfunctional mice.
  Missios P, Zhou Y, Guachalla LM, von Figura G, Wegner A, Chakkarappan SR, Binz T, Gompf A, Hartleben G, Burkhalter MD, Wulff V, Günes C, Sattler RW, Song Z, Illig T, Klaus S, Böhm BO, Wenz T, Hiller K, Rudolph KL
  Nat Commun 2014, 5, 4924
  
• Substantial telomere shortening in the substantia nigra of telomerase-deficient mice does not increase susceptibility to MPTP-induced dopamine depletion.
  Oeckl P, Scheffold A, Lechel A, Rudolph KL, Ferger B
  Neuroreport 2014, 25(5), 335-9 published during change of institution
  
• Effect of cytotoxic chemotherapy on markers of molecular age in patients with breast cancer.
  Sanoff HK, Deal AM, Krishnamurthy J, Torrice C, Dillon P, Sorrentino J, Ibrahim JG, Jolly TA, Williams G, Carey LA, Drobish A, Gordon BB, Alston S, Hurria A, Kleinhans K, Rudolph KL, Sharpless NE, Muss HB
  J Natl Cancer Inst 2014, 106(4), dju057
  
• Aging stem cells: transcriptome meets epigenome meets methylome.
  Tümpel S, Rudolph KL
  Cell Stem Cell 2014, 14(5), 551-2
  
• Senescence and apoptosis block hematopoietic activation of quiescent hematopoietic stem cells with short telomeres.
  Wang J, Lu X, Sakk V, Klein CA, Rudolph KL
  Blood 2014, 124(22), 3237-40
  
• Exonuclease 1 is essential for maintaining genomic stability and the proliferative capacity of neural but not hematopoietic stem cells.
  Zhang J, Yang R, Zhou D, Rudolph KL, Meng A, Ju Z
  Stem Cell Res 2014, 12(1), 250-9
  

2013

• Telomere stability--Wnt it or lose it.
  Bauer K, Tao S, Rudolph KL
  EMBO Rep 2013, 14(4), 297-8
  
• Quantitative proteomic profiling of tumor cell response to telomere dysfunction using isotope-coded protein labeling (ICPL) reveals interaction network of candidate senescence markers.
  Biniossek ML, Lechel A, Rudolph KL, Martens UM, Zimmermann S
  J Proteomics 2013, 91, 515-35 published during change of institution