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Core Facilites and Core Services

At the beginning of 2016, a “core” structure was put into effect that organized facility and service units as independent organizational entities from FLI’s research groups. A number of technology platforms (e.g. sequencing, mass spectrometry) grew out of individual methodological requirements for single research groups in the last years but developed into semiautonomous substructures. As consequence of re-focused research activities and the concomitant advent of new research groups at FLI, those units increasingly had to serve many FLI groups and collaborative research efforts in the Jena research area.

To accommodate this development and to increase efficiency as well as transparency for users, facility personnel and for administrative processes, it came natural to re-organize such activities into independent units as “FLI Core Facilities and Services” and to phase out infrastructures considered non-essential for FLI’s research focus (X-ray crystallography and NMR spectroscopy).

FLI’s Core Facilities (CF) are managed by a CF Manager and are each scientifically guided in their activities and development by an FLI Group Leader, as Scientific Supervisor. The animal facilities comprising fish, mouse and transgenesis are run separately, as they involve a more complex organizational structure. Basic Core Services (CS) are directly led by the Head of Core (HC), who in turn is supported by individual CS Managers.

All facilities and services, including animal facilities, have a valuable contribution to FLI’s research articles; e.g. from 2016–2018, to 54% of all peer reviewed research publications. 

Overview Core Facilities & Services

Overview Core Facilities and Core Services at FLI.

Publications

(since 2016)

2021

  • Isolation, ‘omics characterization and organotypic culture of alveolar type II pulmonary epithelial cells
    Li* H, Schütte* M, Bober* M, Kroll T, Frappart L, Bou About G, Lin YC, Sorg T, Herault Y, Wierling C, Rinner O, Lange Bodo MH, Ploubidou A
    bioRxiv 2021, https://doi.org/10.1101/2021.08. * equal contribution
  • Amyloid precursor protein elevates fusion of promyelocytic leukemia nuclear bodies in human hippocampal areas with high plaque load.
    Marks D, Heinen N, Bachmann L, Meermeyer S, Werner M, Gallego L, Hemmerich P, Bader V, Winklhofer KF, Schröder E, Knauer SK, Müller T
    Acta Neuropathol Commun 2021, 9(1), 66
  • Cooperative treatment effectiveness of ATR and HSP90 inhibition in Ewing's sarcoma cells
    Marx C, Schaarschmidt MU, Kirkpatrick J, Marx-Blümel L, Halilovic M, Westermann M, Hoelzer D, Meyer FB, Geng Y, Buder K, Schadwinkel HM, Siniuk K, Becker S, Thierbach R, Beck JF, Sonnemann* J, Wang* ZQ
    Cell Biosci 2021, 11(1), 57 * equal contribution
  • Molecular characterization of hematopoietic stem cells after in vitro amplification on biomimetic 3D PDMS cell culture scaffolds.
    Marx-Blümel* L, Marx* C, Sonnemann J, Weise F, Hampl J, Frey J, Rothenburger L, Cirri E, Rahnis N, Koch P, Groth M, Schober A, Wang ZQ, Beck JF
    Sci Rep 2021, 11(1), 21163 * equal contribution
  • Intrasexual cuticular hydrocarbon dimorphism in a wasp sheds light on hydrocarbon biosynthesis genes in Hymenoptera
    Moris VC, Podsiadlowski L, Martin S, Oeyen JP, Donath A, Petersen M, Wilbrandt J, Misof B, Liedtke D, Thamm M, Scheiner R, Schmitt T, Niehuis O
    bioRxiv 2021, https://doi.org/10.1101/2021.11.
  • QUAREP-LiMi: A community-driven initiative to establish guidelines for quality assessment and reproducibility for instruments and images in light microscopy
    Nelson G, Boehm U, Bagley S, Bajcsy P, Bischof J, Brown CM, Dauphin A, Dobbie IM, Eriksson JE, Faklaris O, Fernandez-Rodriguez J, Ferrand A, Gelman L, Gheisari A, Hartmann H, Kukat C, Laude A, Mitkovski M, Munck S, North Alison J, Rasse TM, Resch-Genger U, Schuetz LC, Seitz A, Strambio-De-Castillia C, Swedlow Jason R, Alexopoulos I, Aumayr K, Avilov S, Bakker GJ, Bammann Rodrigo R, Bassi A, Beckert H, Beer S, Belyaev Y, Bierwagen J, Birngruber KA, Bosch M, Breitlow J, Cameron LA, Chalfoun J, Chambers JJ, Chen CL, Conde-Sousa E, Corbett AD, Cordelieres FP, Nery ED, Dietzel R, Eismann F, Fazeli E, Felscher A, Fried H, Gaudreault N, Goh WI, Guilbert T, Hadleigh R, Hemmerich P, Holst GA, Itano MS, Jaffe CB, Jambor HK, Jarvis Stuart C, Keppler A, Kirchenbuechler D, Kirchner M, Kobayashi N, Krens G, Kunis S, Lacoste J, Marcello M, Martins Gabriel G, Metcalf DJ, Mitchell CA, Moore J, Mueller T, Nelson MS, Ogg S, Onami S, Palmer AL, Paul-Gilloteaux P, Pimentel Jaime A, Plantard L, Podder S, Rexhepaj E, Royon A, Saari Markku A, Schapman D, Schoonderwoert V, Schroth-Diez B, Schwartz S, Shaw M, Spitaler M, Stoeckl MT, Sudar D, Teillon J, Terjung S, Thuenauer R, Wilms CD, Wright Graham D, Nitschke R
    arXiv 2021, arXiv:2101.09153
  • Correction to: The proteorhodopsins of the dinoflagellate Oxyrrhis marina: ultrastructure and localization by immunofluorescence light microscopy and immunoelectron microscopy.
    Rhiel E, Westermann M, Steiniger F, Hoischen C
    Protoplasma 2021
  • Increased longevity due to sexual activity in mole-rats is associated with transcriptional changes in HPA stress axis.
    Sahm* A, Platzer M, Koch P, Henning Y, Bens M, Groth M, Burda H, Begall S, Ting S, Goetz M, Van Daele P, Staniszewska M, Klose J, Costa PF, Hoffmann** S, Szafranski** K, Dammann** P
    Elife 2021, 10, e57843 ** co-senior authors, * corresponding author
  • An analysis of methylome evolution in primates
    Sahm** A, Koch P, Horvath S, Hoffmann** S
    Mol Biol Evol 2021, 38(11), 4700-14 ** co-corresponding authors
  • NMR-Based Structural Characterization of a Two-Disulfide-Bonded Analogue of the FXIIIa Inhibitor Tridegin: New Insights into Structure-Activity Relationships.
    Schmitz T, Paul George AA, Nubbemeyer B, Bäuml CA, Steinmetzer T, Ohlenschläger O, Biswas A, Imhof D
    Int J Mol Sci 2021, 22(2)