Core Facilites and Core Services

At the beginning of 2016, a “core” structure was put into effect that organized facility and service units as independent organizational entities from FLI’s research groups. A number of technology platforms (e.g. sequencing, mass spectrometry) grew out of individual methodological requirements for single research groups in the last years but developed into semiautonomous substructures. As consequence of re-focused research activities and the concomitant advent of new research groups at FLI, those units increasingly had to serve many FLI groups and collaborative research efforts in the Jena research area.

To accommodate this development and to increase efficiency as well as transparency for users, facility personnel and for administrative processes, it came natural to re-organize such activities into independent units as “FLI Core Facilities and Services” and to phase out infrastructures considered non-essential for FLI’s research focus (X-ray crystallography and NMR spectroscopy).

FLI’s Core Facilities (CF) are managed by a CF Manager and are each scientifically guided in their activities and development by an FLI Group Leader, as Scientific Supervisor. The animal facilities comprising fish, mouse and transgenesis are run separately, as they involve a more complex organizational structure. Basic Core Services (CS) are directly led by the Head of Core (HC), who in turn is supported by individual CS Managers.

All facilities and services, including animal facilities, have a valuable contribution to FLI’s research articles; e.g. from 2016–2018, to 54% of all peer reviewed research publications.

Overview Core Facilities and Core Services at FLI.

Publications

(since 2016)

2020

The proteorhodopsins of the dinoflagellate Oxyrrhis marina: ultrastructure and localization by immunofluorescence light microscopy and immunoelectron microscopy.
Rhiel E, Westermann M, Steiniger F, Hoischen C
Protoplasma 2020, 257(6), 1531-41
Elevated Hedgehog activity contributes to attenuated DNA damage responses in aged hematopoietic cells.
Scheffold A, Baig AH, Chen Z, von Löhneysen SE, Becker F, Morita Y, Avila AI, Groth M, Lechel A, Schmid F, Kraus JM, Kestler HA, Stilgenbauer S, Philipp M, Burkhalter MD
Leukemia 2020, 34(4), 1125-34
The stress-responsive gene GDPGP1/mcp-1 regulates neuronal glycogen metabolism and survival.
Schulz A, Sekine Y, Oyeyemi MJ, Abrams AJ, Basavaraju M, Han SM, Groth M, Morrison H, Strittmatter SM, Hammarlund M
J Cell Biol 2020, 219(2), doi: 10.1083/jcb.201807127
High-affinity binding and catalytic activity of His/Tyr-based sequences: Extending heme-regulatory motifs beyond CP.
Syllwasschy BF, Beck MS, Družeta I, Hopp MT, Ramoji A, Neugebauer U, Nozinovic S, Menche D, Willbold D, Ohlenschläger O, Kühl T, Imhof D
Bba-Gen Subjects 2020, 1864(7), 129603
Comparison of Multiscale Imaging Methods for Brain Research.
Tröger J, Hoischen C, Perner B, Monajembashi S, Barbotin A, Löschberger A, Eggeling C, Kessels** MM, Qualmann** B, Hemmerich** P
Cells 2020, 9(6), E1377 ** co-corresponding authors
Active neutrophil responses counteract Candida albicans burn wound infection of ex vivo human skin explants.
von Müller C, Bulman F, Wagner L, Rosenberger D, Marolda A, Kurzai O, Eißmann P, Jacobsen ID, Perner B, Hemmerich P, Vylkova S
Sci Rep 2020, 10(1), 21818
Cysteines and Disulfide Bonds as Structure-Forming Units: Insights From Different Domains of Life and the Potential for Characterization by NMR.
Wiedemann C, Kumar A, Lang A, Ohlenschläger O
Front Chem 2020, 8, 280
Novel reassortant swine H3N2 influenza A viruses in Germany.
Zell R, Groth M, Krumbholz A, Lange J, Philipps A, Dürrwald R
Sci Rep 2020, 10(1), 14296
Displacement of the Gent/1999 human-like swine H1N2 influenza A virus lineage by novel H1N2 reassortants in Germany.
Zell R, Groth M, Krumbholz A, Lange J, Philipps A, Dürrwald R
Arch Virol 2020, 165(1), 55-67
Cocirculation of Swine H1N1 Influenza A Virus Lineages in Germany.
Zell R, Groth M, Krumhbolz A, Lange J, Philipps A, Dürrwald R
Viruses 2020, 12(7), E762