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Core Facilites and Core Services

At the beginning of 2016, a “core” structure was put into effect that organized facility and service units as independent organizational entities from FLI’s research groups. A number of technology platforms (e.g. sequencing, mass spectrometry) grew out of individual methodological requirements for single research groups in the last years but developed into semiautonomous substructures. As consequence of re-focused research activities and the concomitant advent of new research groups at FLI, those units increasingly had to serve many FLI groups and collaborative research efforts in the Jena research area.

To accommodate this development and to increase efficiency as well as transparency for users, facility personnel and for administrative processes, it came natural to re-organize such activities into independent units as “FLI Core Facilities and Services” and to phase out infrastructures considered non-essential for FLI’s research focus (X-ray crystallography and NMR spectroscopy).

FLI’s Core Facilities (CF) are managed by a CF Manager and are each scientifically guided in their activities and development by an FLI Group Leader, as Scientific Supervisor. The animal facilities comprising fish, mouse and transgenesis are run separately, as they involve a more complex organizational structure. Basic Core Services (CS) are directly led by the Head of Core (HC), who in turn is supported by individual CS Managers.

All facilities and services, including animal facilities, have a valuable contribution to FLI’s research articles; e.g. from 2016–2018, to 54% of all peer reviewed research publications. 

Overview Core Facilities & Services

Overview Core Facilities and Core Services at FLI.

Publications

(since 2016)

2020

  • CD44 (Cluster of differentiation 44) promotes osteosarcoma progression in mice lacking the tumor suppressor Merlin.
    Ma* J, Klemm* J, Gerardo-Ramírez M, Frappart L, Castven D, Becker D, Zoch A, Parent R, Bartosch B, Minnich K, Giovannini M, Danckwardt S, Hartmann N, Morrison H, Herrlich** P, Marquardt** JU, Hartmann** M
    Int J Cancer 2020, 147(9), 2564-77 * equal contribution, ** co-senior authors
  • Biomimetic reconstruction of the hematopoietic stem cell niche for in vitro amplification of human hematopoietic stem cells.
    Marx-Blümel L, Marx C, Weise F, Frey J, Perner B, Schlingloff G, Lindig N, Hampl J, Sonnemann J, Brauer D, Voigt A, Singh S, Beck B, Jäger UM, Wang ZQ, Beck JF, Schober A
    PLoS One 2020, 15(6), e0234638
  • The genome, transcriptome, and proteome of the fish parasite Pomphorhynchus laevis (Acanthocephala).
    Mauer K, Hellmann SL, Groth M, Fröbius AC, Zischler H, Hankeln T, Herlyn H
    PLoS One 2020, 15(6), e0232973
  • MiR-29 coordinates age-dependent plasticity brakes in the adult visual cortex.
    Napoli D, Lupori L, Mazziotti R, Sagona G, Bagnoli S, Samad M, Sacramento EK, Kirkpartick J, Putignano E, Chen S, Terzibasi Tozzini E, Tognini P, Baldi P, Kwok JC, Cellerino* A, Pizzorusso* T
    EMBO Rep 2020, 21(11), e50431 * equal contribution
  • Aneuploidy-inducing gene knockdowns overlap with cancer mutations and identify Orp3 as a B-cell lymphoma suppressor.
    Njeru* SN, Kraus* J, Meena* JK, Lechel A, Katz SF, Kumar M, Knippschild U, Azoitei A, Wezel F, Bolenz C, Leithäuser F, Gollowitzer A, Omrani O, Hoischen C, Koeberle A, Kestler** HA, Günes** C, Rudolph** KL
    Oncogene 2020, 39(7), 1445-65 * equal contribution, ** co-corresponding authors
  • The Nucleus of Intestinal Cells of the Bacterivore Nematode Caenorhabditis elegans as a Sensitive Sensor of Environmental Pollutants.
    Piechulek A, Berwanger L, Hemmerich P, von Mikecz A
    Methods Mol Biol 2020, 2175, 207-17
  • Adaptive divergence across Southern Ocean gradients in the pelagic diatom Fragilariopsis kerguelensis.
    Postel U, Glemser B, Salazar Alekseyeva K, Eggers SL, Groth M, Glöckner G, John U, Mock T, Klemm K, Valentin K, Beszteri B
    Mol Ecol 2020, 29(24), 4913-24
  • The proteorhodopsins of the dinoflagellate Oxyrrhis marina: ultrastructure and localization by immunofluorescence light microscopy and immunoelectron microscopy.
    Rhiel E, Westermann M, Steiniger F, Hoischen C
    Protoplasma 2020, 257(6), 1531-41
  • Elevated Hedgehog activity contributes to attenuated DNA damage responses in aged hematopoietic cells.
    Scheffold A, Baig AH, Chen Z, von Löhneysen SE, Becker F, Morita Y, Avila AI, Groth M, Lechel A, Schmid F, Kraus JM, Kestler HA, Stilgenbauer S, Philipp M, Burkhalter MD
    Leukemia 2020, 34(4), 1125-34
  • The stress-responsive gene GDPGP1/mcp-1 regulates neuronal glycogen metabolism and survival.
    Schulz A, Sekine Y, Oyeyemi MJ, Abrams AJ, Basavaraju M, Han SM, Groth M, Morrison H, Strittmatter SM, Hammarlund M
    J Cell Biol 2020, 219(2), doi: 10.1083/jcb.201807127