Subarea 1: Stem Cell Aging
The individual research groups within Subarea 1 investigate the causes and consequences of stem cell aging. The research work spans from basic model organisms over genetic mouse models up to humanized mouse models engrafted with human stem cells.
According to the FLI, with the closure of two groups since 2016 the representation of invertebrate models of stem cell research was reduced in Subarea 1. The institute presumes that the recruitment of new groups should fill this gap.
The research is defined by four focus areas:
- Cell-intrinsic mechanisms limiting the function of aging stem and progenitor cells,
- Aging-associated alterations of stem cell niches and the systemic environment,
- Mechanisms of clonal selection and epigenetic drifts in stem cell aging, and
- Microbiota- and metabolism-induced impairments in stem cell function during aging (in context of the new focus area Microbiota and Aging currently being built up within Subarea 2).
Research focus of Subarea 1.
a) It is currently not well understood what mechanisms impair cellular functions in aging. b) The relative contribution of niche cells and systemic acting factors on stem cell aging have yet to be determined in different tissues. c) Clonal expansion of mutant cells associates with disease development in aging humans. Mechanistically, the process remains poorly understood. Changes in color intensity depict clonal dominance originating from stem (green) or progenitor cells (gray). d) Emerging evidences indicate that aging associated alter ations in microbiota influence stem cell function and vice versa.
Publications
(since 2016)
2019
- Developmental origin, functional maintenance and genetic rescue of osteoclasts.
Jacome-Galarza* CE, Percin* GI, Muller* JT, Mass* E, Lazarov T, Eitler J, Rauner M, Yadav VK, Crozet L, Bohm M, Loyher PL, Karsenty G, Waskow** C, Geissmann** F
Nature 2019, 568(7753), 541-5 * equal contribution, ** co-corresponding authors - The acetyltransferase GCN5 maintains ATRA-resistance in non-APL AML.
Kahl M, Brioli A, Bens M, Perner F, Kresinsky A, Schnetzke U, Hinze A, Sbirkov Y, Stengel S, Simonetti G, Martinelli G, Petrie K, Zelent A, Böhmer FD, Groth M, Ernst T, Heidel FH, Scholl S, Hochhaus A, Schenk T
Leukemia 2019, 33(11), 2628-39 - Sirt1 deletion improves intestinal atrophy in telomere dysfunctional mice by impairing induction of DNA damage responses
Kim I
Dissertation 2019, Jena, Germany - The WT1-like transcription factor Klumpfuss maintains lineage commitment of enterocyte progenitors in the Drosophila intestine.
Korzelius** J, Azami S, Ronnen-Oron T, Koch P, Baldauf M, Meier E, Rodriguez-Fernandez IA, Groth M, Sousa-Victor P, Jasper** H
Nat Commun 2019, 10(1), 4123 ** co-corresponding authors - The peripheral differentiation of human natural killer T cells.
Liu J, Hill BJ, Darko S, Song K, Quigley MF, Asher TE, Morita Y, Greenaway HY, Venturi V, Douek DC, Davenport MP, Price DA, Roederer M
Immunol Cell Biol 2019, 97(6), 586-96 - Memantine potentiates cytarabine-induced cell death of acute leukemia correlating with inhibition of Kv 1.3 potassium channels, AKT and ERK1/2 signaling.
Lowinus T, Heidel FH, Bose T, Nimmagadda SC, Schnöder T, Cammann C, Schmitz I, Seifert U, Fischer T, Schraven B, Bommhardt U
Cell Commun Signal 2019, 17(1), 5 - Prospective isolation of non-hematopoietic cells of the niche and their differential molecular interactions with HSCs.
Mende* N, Jolly* A, Percin* GI, Günther M, Rostovskaya M, Krishnan SM, Oostendorp RAJ, Dahl A, Anastassiadis K, Höfer** T, Waskow** C
Blood 2019, 134(15), 1214-26 * equal contribution, ** co-senior authors - Differences in expression rather than methylation at placenta-specific imprinted loci is associated with intrauterine growth restriction.
Monteagudo-Sánchez A, Sánchez-Delgado M, Mora JRH, Santamaría NT, Gratacós E, Esteller M, de Heredia ML, Nunes V, Choux C, Fauque P, de Nanclares GP, Anton L, Elovitz MA, Iglesias-Platas I, Monk D
Clin Epigenetics 2019, 11(1), 35 - ORP3 is a tumor suppressor protein in the B-cell lineage of aging mice
Njeru SN
Dissertation 2019, Jena, Germany - Plasma VCAM1 levels correlate with disease severity in Parkinson's disease.
Perner C, Perner F, Gaur N, Zimmermann S, Witte OW, Heidel FH, Grosskreutz J, Prell T
J Neuroinflammation 2019, 16(1), 94
