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Home>Research>Subarea 2: Regeneration and Homeostasis of Organs in Aging
Research focus of Subarea 2.

Subarea 2: Regeneration and Homeostasis of Organs in Aging

The main goal of Subarea 2 is to identify cellular and molecular pathways used to ensure effective organ maintenance and repair, and to unravel the mechanisms of their deterioration during aging. While stem cells are important for organ homeostasis, this Subarea does not per se directly addresses stem cell aging but rather focusses on the following focus areas:

  • Drifts in developmental pathways limiting organ maintenance in aging,
  • Immune aging and inflammation, and
  • Systemic and micro-milieu regulators of organ maintenance, regeneration, and disease development.

Research focus of Subarea 2

Organ maintenance is regulated by local and systemic factors, which are subject to aging-associated changes. Research of Subarea 2 focuses on the following research areas: a) Genetic and epigenetic modulation of developmental pathways has been shown to contribute to progressive aging and disease. It is critical to delineate mechanisms and consequences of aging-associated drifts to better understand organ maintenance during aging. b) Immunoaging and chronic inflammation elicits negative effects through reduced immune surveillance and aberrant organ repair and maintenance; all of which contributes to the evolution of organ pathologies and diseases during organismal aging. c) Furthermore, aging-associated alterations in systemic and extracellular factors derived from metabolic changes, microbiota alterations, chronic inflammation, senescent, or damaged cells might impinge on disease development and tumor initiation.

Publications

(since 2016)

2023

  • Spontaneous onset of cellular markers of inflammation and genome instability during aging in the immune niche of the naturally short-lived turquoise killifish (Nothobranchius furzeri)
    Morabito G, Dönertas HM, Seidel J, Poursadegh A, Poeschla M, Valenzano DR
    bioRxiv 2023
  • Sperm production is negatively associated with muscle and sperm telomere length in a species subjected to strong sperm competition.
    Morbiato E, Cattelan S, Pilastro A, Grapputo A
    Mol Ecol 2023, 32(31), 5812-22
  • Microbiome and immuno-metabolic dysregulation in patients with major depressive disorder with atypical clinical presentation.
    Refisch A, Sen ZD, Klassert TE, Busch A, Besteher B, Danyeli LV, Helbing D, Schulze-Späte U, Stallmach A, Bauer M, Panagiotou G, Jacobsen ID, Slevogt H, Opel N, Walter M
    Neuropharmacology 2023, 235, 109568
  • Sequencing the Immunoglobulin Heavy-Chain Locus (IgH) in Turquoise Killifish ( Nothobranchius furzeri).
    Seidel J, Bradshaw WJ, Valenzano DR
    Cold Spring Harb Protoc 2023, 5
  • Taxonomic Profiling of Fecal and Intestinal Microbiota in the African Turquoise Killifish Nothobranchius furzeri.
    Seidel J, Popkes M, Valenzano DR
    Cold Spring Harb Protoc 2023, 2023(10), 755-62 published during change of institution
  • Corrigendum: Taxonomic Profiling of Fecal and Intestinal Microbiota in the African Turquoise Killifish Nothobranchius furzeri.
    Seidel J, Popkes M, Valenzano DR
    Cold Spring Harb Protoc 2023, 2023(10), pdb.corr108388 published during change of institution
  • Peripheral Nerve Ageing Maintenance, repair, and CCL11 as an ageing factor
    Stockdale A
    Dissertation 2023, Jena, Germany
  • Cre recombinase expression cooperates with homozygous FLT3 internal tandem duplication knockin mouse model to induce acute myeloid leukemia.
    Straube* J, Eifert* T, Vu T, Janardhanan Y, Haldar R, von Eyss B, Cooper L, Bruedigam C, Ling VY, Cooper E, Patch AM, Bullinger L, Schnoeder TM, Bywater M, Heidel* FH, Lane* SW
    Leukemia 2023, 37(4), 741 * equal contribution
  • TRPS1 maintains luminal progenitors in the mammary gland by repressing SRF/MRTF activity
    Tollot-Wegner M, Jessen M, Kim K, Sanz-Moreno A, Spielmann N, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, von Eyss B
    bioRxiv 2023, 10.1101/2023.11.24.568520
  • Immunoproteasome function maintains oncogenic gene expression in KMT2A-complex driven leukemia.
    Tubío-Santamaría N, Jayavelu AK, Schnoeder TM, Eifert T, Hsu CJ, Perner F, Zhang Q, Wenge DV, Hansen FM, Kirkpatrick JM, Jyotsana N, Lane SW, von Eyss B, Deshpande AJ, Kühn MWM, Schwaller J, Cammann C, Seifert U, Ebstein F, Krüger E, Hochhaus A, Heuser M, Ori A, Mann M, Armstrong SA, Heidel FH
    Mol Cancer 2023, 22(1), 196