Subarea 3: Genetics and Epigenetics of Aging

The focus of Subarea 3 is on genetic and epigenetic determinants of life- and health span as well as aging in fish, rodents and humans. This line of research builds on the expertise of the institute in comparative and functional genomics.

The research is defined by five focus areas:

  • Comparative genomics in short- and long-lived models of aging,
  • Genomic engineering in N. furzeri,
  • Epigenetics of aging,
  • Non-coding RNAs in aging, and
  • Comparative transcriptomics of aging.

Research focus of Subarea 3.

To uncover causative factors for aging, comparative genomics in short- and long-lived model systems are applied. Functional genomics is used to identify novel pathways contribute to aging of an organism and to validate the functional relevance of genetic and epigenetic changes that occur during aging. Furthermore, genetic risk factors for aging-related diseases are identified and functionally tested. The future development of the Subarea aims to integrate changes in host-microbiota interactions during aging, and how these influence clonal mutation and epigenetic alterations through metabolites and other signals.

Publications

(since 2016)

2019

  • The nuclear pore proteins Nup88/214 and T-ALL-associated NUP214 fusion proteins regulate Notch signaling.
    Kindermann B, Valkova C, Krämer A, Perner B, Engelmann C, Behrendt L, Kritsch D, Jungnickel B, Kehlenbach RH, Oswald F, Englert C, Kaether C
    J Biol Chem 2019, 294(31), 11741-50
  • IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma.
    Kofuji S, Hirayama A, Eberhardt AO, Kawaguchi R, Sugiura Y, Sampetrean O, Ikeda Y, Warren M, Sakamoto N, Kitahara S, Yoshino H, Yamashita D, Sumita K, Wolfe K, Lange L, Ikeda S, Shimada H, Minami N, Malhotra A, Morioka S, Ban Y, Asano M, Flanary VL, Ramkissoon A, Chow LML, Kiyokawa J, Mashimo T, Lucey G, Mareninov S, Ozawa T, Onishi N, Okumura K, Terakawa J, Daikoku T, Wise-Draper T, Majd N, Kofuji K, Sasaki M, Mori M, Kanemura Y, Smith EP, Anastasiou D, Wakimoto H, Holland EC, Yong WH, Horbinski C, Nakano I, DeBerardinis RJ, Bachoo RM, Mischel PS, Yasui W, Suematsu M, Saya H, Soga T, Grummt I, Bierhoff H, Sasaki AT
    Nat Cell Biol 2019, 21(8), 1003-14
  • Identification and Expression of Neurotrophin-6 in the Brain of Nothobranchius furzeri: One More Piece in Neurotrophin Research.
    Leggieri A, Attanasio C, Palladino A, Cellerino A, Lucini C, Paolucci M, Terzibasi Tozzini E, de Girolamo P, D'Angelo L
    J Clin Med 2019, 8(5), 595
  • Age-related central regulation of orexin and NPY in the short lived African killifish Nothobranchius furzeri.
    Montesano* A, Baumgart* M, Avallone L, Castaldo L, Lucini C, Terzibasi Tozzini E, Cellerino** A, D'Angelo** L, de Girolamo** P
    J Comp Neurol 2019, 527(9), 1508-26 * equal contribution, ** co-senior authors
  • Identification of miRNAs and associated pathways regulated by Leukemia Inhibitory Factor in trophoblastic cell lines.
    Morales-Prieto DM, Barth E, Murrieta-Coxca JM, Favaro RR, Gutiérrez-Samudio RN, Chaiwangyen W, Ospina-Prieto S, Gruhn B, Schleußner E, Marz* M, Markert* UR
    Placenta 2019, 88, 20-7 * equal contribution
  • Repair, regenerate and reconstruct: meeting the state-of-the-art.
    Reuter H, Vogg MC, Serras F
    Development 2019, 146(9)
  • Analysis of the coding sequences of clownfish reveals molecular convergence in the evolution of lifespan.
    Sahm A, Almaida-Pagán P, Bens M, Mutalipassi M, Lucas-Sánchez A, de Costa Ruiz J, Görlach M, Cellerino A
    BMC Evol Biol 2019, 19(1), 89
  • Wilms Tumor 1b Expression Defines a Pro-regenerative Macrophage Subtype and Is Required for Organ Regeneration in the Zebrafish.
    Sanz-Morejón A, García-Redondo AB, Reuter H, Marques IJ, Bates T, Galardi-Castilla M, Große A, Manig S, Langa X, Ernst A, Piragyte I, Botos MA, González-Rosa JM, Ruiz-Ortega M, Briones AM, Salaices M, Englert C, Mercader N
    Cell Rep 2019, 28(5), 1296-1306.e6
  • Author Correction: Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals.
    Schwörer S, Becker F, Feller C, Baig AH, Köber U, Henze H, Kraus JM, Xin B, Lechel A, Lipka DB, Varghese CS, Schmidt M, Rohs R, Aebersold R, Medina KL, Kestler HA, Neri F, von Maltzahn** J, Tümpel** S, Rudolph** KL
    Nature 2019, 572(7769), E11-5 ** co-corresponding authors
  • The landscape of the alternatively spliced transcriptome remains stable during aging across different species and tissues.
    Sieber P, Barth* E, Marz* M
    bioRxiv 2019, https://doi.org/10.1101/541417 * equal contribution