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Home>Research>Subarea 3: Genetics and Epigenetics of Aging
Research focus of Subarea 3.

Subarea 3: Genetics and Epigenetics of Aging

The focus of Subarea 3 is on genetic and epigenetic determinants of life- and health span as well as aging in fish, rodents and humans. This line of research builds on the expertise of the institute in comparative and functional genomics.

The research is defined by five focus areas:

  • Comparative genomics in short- and long-lived models of aging,
  • Genomic engineering in N. furzeri,
  • Epigenetics of aging,
  • Non-coding RNAs in aging, and
  • Comparative transcriptomics of aging.

Research focus of Subarea 3.

To uncover causative factors for aging, comparative genomics in short- and long-lived model systems are applied. Functional genomics is used to identify novel pathways contribute to aging of an organism and to validate the functional relevance of genetic and epigenetic changes that occur during aging. Furthermore, genetic risk factors for aging-related diseases are identified and functionally tested. The future development of the Subarea aims to integrate changes in host-microbiota interactions during aging, and how these influence clonal mutation and epigenetic alterations through metabolites and other signals.

Publications

(since 2016)

2018

  • Moderate H-Ras activation decreases the health span in Costello syndrome mouse model : novel H-RasG12V - driven advanced aging phenotyp.
    Chennappan S
    Dissertation 2018, Jena, Germany
  • Temperature throws a developmental switch.
    Englert C
    Proc Natl Acad Sci U S A 2018, 115(50), 12553-5
  • Cellular and epigenetic drivers of stem cell ageing.
    Ermolaeva** M, Neri** F, Ori** A, Rudolph** KL
    Nat Rev Mol Cell Biol 2018, 19(9), 594-610 ** co-corresponding authors
  • Integrative analysis of differentially expressed genes and miRNAs predicts complex T3-mediated protective circuits in a rat model of cardiac ischemia reperfusion.
    Forini F, Nicolini G, Kusmic C, D'Aurizio R, Rizzo M, Baumgart M, Groth M, Doccini S, Iervasi G, Pitto L
    Sci Rep 2018, 8(1), 13870
  • Googles DeepVariant: eine Methode für die Medizin- und Bioinformatik?
    Fürstberger** A, Platzer** M, Kestler** HA
    BIOspektrum 2018, 24(3), 235–235 ** co-corresponding authors
  • Effects of allelic variations in the human Myxovirus resistance protein A on its antiviral activity.
    Graf L, Dick A, Sendker F, Barth E, Marz M, Daumke O, Kochs G
    J Biol Chem 2018, 293(9), 3056-72
  • Species comparison of liver proteomes reveals links to naked mole-rat longevity and human aging.
    Heinze* I, Bens* M, Calzia* E, Holtze S, Dakhovnik O, Sahm A, Kirkpatrick JM, Szafranski K, Romanov N, Sama SN, Holzer K, Singer S, Ermolaeva M, Platzer** M, Hildebrandt** T, Ori** A
    BMC Biol 2018, 16(1), 82 * equal contribution, ** co-senior authors
  • Multiple roots of fruiting body formation in Amoebozoa.
    Hillmann F, Forbes G, Novohradská S, Ferling I, Riege K, Groth M, Westermann M, Marz M, Spaller T, Winckler T, Schaap P, Glöckner G
    Genome Biol Evol 2018, 10(2), 591-606
  • The microenvironment of naked mole-rat burrows in East Africa
    Holtze S, Braude S, Lemma A, Koch R, Morhart M, Szafranski K, Platzer M, Alemayehu F, Goeritz F, Hildebrandt TB
    Afr J Ecol 2018, 56(2), 279-89
  • 3D Network exploration and visualisation for lifespan data.
    Hühne* R, Kessler* V, Fürstberger* A, Kühlwein S, Platzer M, Sühnel J, Lausser L, Kestler HA
    BMC Bioinformatics 2018, 19(1), 390 * equal contribution