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Home>Research>Subarea 3: Genetics and Epigenetics of Aging
Research focus of Subarea 3.

Subarea 3: Genetics and Epigenetics of Aging

The focus of Subarea 3 is on genetic and epigenetic determinants of life- and health span as well as aging in fish, rodents and humans. This line of research builds on the expertise of the institute in comparative and functional genomics.

The research is defined by five focus areas:

  • Comparative genomics in short- and long-lived models of aging,
  • Genomic engineering in N. furzeri,
  • Epigenetics of aging,
  • Non-coding RNAs in aging, and
  • Comparative transcriptomics of aging.

Research focus of Subarea 3.

To uncover causative factors for aging, comparative genomics in short- and long-lived model systems are applied. Functional genomics is used to identify novel pathways contribute to aging of an organism and to validate the functional relevance of genetic and epigenetic changes that occur during aging. Furthermore, genetic risk factors for aging-related diseases are identified and functionally tested. The future development of the Subarea aims to integrate changes in host-microbiota interactions during aging, and how these influence clonal mutation and epigenetic alterations through metabolites and other signals.

Publications

(since 2016)

2018

  • The microenvironment of naked mole-rat burrows in East Africa
    Holtze S, Braude S, Lemma A, Koch R, Morhart M, Szafranski K, Platzer M, Alemayehu F, Goeritz F, Hildebrandt TB
    Afr J Ecol 2018, 56(2), 279-89
  • 3D Network exploration and visualisation for lifespan data.
    Hühne* R, Kessler* V, Fürstberger* A, Kühlwein S, Platzer M, Sühnel J, Lausser L, Kestler HA
    BMC Bioinformatics 2018, 19(1), 390 * equal contribution
  • Bioinformatics Meets Virology: The European Virus Bioinformatics Center's Second Annual Meeting.
    Ibrahim B, Arkhipova K, Andeweg AC, Posada-Céspedes S, Enault F, Gruber A, Koonin EV, Kupczok A, Lemey P, McHardy AC, McMahon DP, Pickett BE, Robertson DL, Scheuermann RH, Zhernakova A, Zwart MP, Schönhuth A, Dutilh BE, Marz M
    Viruses 2018, 10(5, 256; https://doi.org/10.33
  • Epigenetic Erosion in Adult Stem Cells: Drivers and Passengers of Aging.
    Kosan C, Heidel FH, Godmann M, Bierhoff H
    Cells 2018, 7(12)
  • Identification of potential microRNAs associated with Herpesvirus family based on bioinformatic analysis.
    Lamkiewicz K, Barth E, Marz** M, Ibrahim** B
    bioRxiv 2018, https://doi.org/10.1101/417782 ** co-corresponding authors
  • Wilms Tumor 1b defines a wound-specific sheath cell subpopulation associated with notochord repair.
    Lopez-Baez JC, Simpson DJ, LLeras Forero L, Zeng Z, Brunsdon H, Salzano A, Brombin A, Wyatt C, Rybski W, Huitema LFA, Dale RM, Kawakami K, Englert C, Chandra T, Schulte-Merker S, Hastie ND, Patton EE
    Elife 2018, 7, e30657
  • Structural and functional conservation of cis-acting RNA elements in coronavirus 5'-terminal genome regions.
    Madhugiri R, Karl N, Petersen D, Lamkiewicz K, Fricke M, Wend U, Scheuer R, Marz M, Ziebuhr J
    Virology 2018, 517, 44-55
  • The age-regulated zinc finger factor ZNF367 is a new modulator of neuroblast proliferation during embryonic neurogenesis.
    Naef V, Monticelli S, Corsinovi D, Mazzetto MT, Cellerino A, Ori M
    Sci Rep 2018, 8(1), 11836
  • Dispersion/reaggregation in early development of annual killifishes: Phylogenetic distribution and evolutionary significance of a unique feature.
    Naumann B, Englert C
    Dev Biol 2018, 442(1), 69-79
  • The impact of the Wilms tumor suppressor genes on zebrafish kidney regeneration.
    Naumann U
    Dissertation 2018, Jena, Germany