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Home>Research>Subarea 3: Genetics and Epigenetics of Aging
Research focus of Subarea 3.

Subarea 3: Genetics and Epigenetics of Aging

The focus of Subarea 3 is on genetic and epigenetic determinants of life- and health span as well as aging in fish, rodents and humans. This line of research builds on the expertise of the institute in comparative and functional genomics.

The research is defined by five focus areas:

  • Comparative genomics in short- and long-lived models of aging,
  • Genomic engineering in N. furzeri,
  • Epigenetics of aging,
  • Non-coding RNAs in aging, and
  • Comparative transcriptomics of aging.

Research focus of Subarea 3.

To uncover causative factors for aging, comparative genomics in short- and long-lived model systems are applied. Functional genomics is used to identify novel pathways contribute to aging of an organism and to validate the functional relevance of genetic and epigenetic changes that occur during aging. Furthermore, genetic risk factors for aging-related diseases are identified and functionally tested. The future development of the Subarea aims to integrate changes in host-microbiota interactions during aging, and how these influence clonal mutation and epigenetic alterations through metabolites and other signals.

Publications

(since 2016)

2021

  • Establishment of a fluorescent reporter of RNA-polymerase II activity to identify dormant cells
    Freter R, Falletta P, Omrani O, Rasa M, Herbert K, Annunziata F, Minetti A, Krepelova A, Adam L, Käppel S, Rüdiger T, Wang ZQ, Goding** CR, Neri** F
    Nat Commun 2021, 12(1), 3318 ** co-corresponding authors
  • ITN-VIROINF: Understanding (Harmful) Virus-Host Interactions by Linking Virology and Bioinformatics.
    Goettsch W, Beerenwinkel** N, Deng** L, Dölken** L, Dutilh** BE, Erhard** F, Kaderali** L, von Kleist** M, Marquet R, Matthijnssens** J, McCallin S, McMahon** D, Rattei T, Van Rij** RP, Robertson** DL, Schwemmle** M, Stern-Ginossar N, Marz** M
    Viruses 2021, 13(5) ** co-corresponding authors
  • RNA:DNA triple helices: from peculiar structures to pervasive chromatin regulators.
    Greifenstein* AA, Jo* S, Bierhoff H
    Essays Biochem 2021, 65(4), 731-40 * equal contribution
  • Regeneration in starved planarians depends on TRiC/CCT subunits modulating the unfolded protein response.
    Gutiérrez-Gutiérrez* Ó, Felix* DA, Salvetti A, Amro EM, Thems A, Pietsch S, Koeberle A, Rudolph KL, González-Estévez C
    EMBO Rep 2021, 22(8), e52905 * equal contribution
  • Alternative Animal Models of Aging Research
    Holtze S, Gorshkova E, Braude S, Cellerino A, Dammann P, Hildebrandt TB, Hoeflich A, Hoffmann S, Koch P, Terzibasi Tozzini E, Skulachev M, Skulachev VP, Sahm A
    Front Mol Biosci 2021, 8, doi: 10.3389/fmolb.2021.660959.
  • PoSeiDon: a Nextflow pipeline for the detection of evolutionary recombination events and positive selection.
    Hölzer M, Marz M
    Bioinformatics 2021, 37(7), 1018-20
  • Low-Input Whole-Genome Bisulfite Sequencing.
    Krepelova A, Neri F
    Methods Mol Biol 2021, 2351, 353-68
  • Generating a transparent vertebrate model for in vivo applications in aging research
    Krug J
    Dissertation 2021, Jena, Germany
  • Systems Analysis Reveals Ageing-Related Perturbations in Retinoids and Sex Hormones in Alzheimer's and Parkinson's Diseases.
    Lam S, Hartmann N, Benfeitas R, Zhang C, Arif M, Turkez H, Uhlén M, Englert C, Knight R, Mardinoglu A
    Biomedicines 2021, 9(10), 1310
  • Characterization of an in vitro 3D intestinal organoid model by using massive RNAseq-based transcriptome profiling.
    Lu J, Krepelova A, Rasa SMM, Annunziata F, Husak O, Adam L, Nunna S, Neri F
    Sci Rep 2021, 11(1), 16668