Subarea 3: Genetics and Epigenetics of Aging
The focus of Subarea 3 is on genetic and epigenetic determinants of life- and health span as well as aging in fish, rodents and humans. This line of research builds on the expertise of the institute in comparative and functional genomics.
The research is defined by five focus areas:
- Comparative genomics in short- and long-lived models of aging,
- Genomic engineering in N. furzeri,
- Epigenetics of aging,
- Non-coding RNAs in aging, and
- Comparative transcriptomics of aging.
Research focus of Subarea 3.
To uncover causative factors for aging, comparative genomics in short- and long-lived model systems are applied. Functional genomics is used to identify novel pathways contribute to aging of an organism and to validate the functional relevance of genetic and epigenetic changes that occur during aging. Furthermore, genetic risk factors for aging-related diseases are identified and functionally tested. The future development of the Subarea aims to integrate changes in host-microbiota interactions during aging, and how these influ ence clonal mutation and epigenetic alterations through metabolites and other signals.
Publications
(since 2016)
2018
- Exploring the basis of naked mole-rat healthspan by characterization of its transsulfuration pathway and hydroxymethylome.
Olecka MK
Dissertation 2018, Jena, Germany - Loss of Wilms tumor 1 protein is a marker for apoptosis in response to replicative stress in leukemic cells.
Pons* M, Reichardt* CM, Hennig D, Nathan A, Kiweler N, Stocking C, Wichmann C, Christmann M, Butter F, Reichardt S, Schneider G, Heinzel T, Englert C, Hartkamp J, Krämer OH, Mahendrarajah N
Arch Toxicol 2018, 92(6), 2119-35 * equal contribution - The Pseudogenes of Barley.
Prade VM, Gundlach H, Twardziok S, Chapman B, Tan C, Langridge P, Schulman AH, Stein N, Waugh R, Zhang G, Platzer M, Li C, Spannagl M, Mayer KFX
Plant J 2018, 93(3), 502-14 - Impairing L-Threonine Catabolism Promotes Healthspan through Methylglyoxal-Mediated Proteohormesis.
Ravichandran M, Priebe S, Grigolon G, Rozanov L, Groth M, Laube B, Guthke R, Platzer M, Zarse K, Ristow M
Cell Metab 2018, 27(4), 914-25 - Haplotypes composed of minor frequency single nucleotide polymorphism of tnf gene protect from progression into sepsis: A study using the new sepsis classification.
Retsas T, Huse K, Lazaridis LD, Karampela N, Bauer M, Platzer M, Kolonia V, Papageorgiou E, Giamarellos-Bourboulis EJ, Dimopoulos G
Int J Infect Dis 2018, 67, 102-6 - The African turquoise killifish Nothobranchius furzeri as amodel for aging research
Reuter* H, Singer* P, Krug* J, Englert C
Drug Discovery Today: Disease Models 2018, 27, 15-22 * equal contribution - Higher gene expression stability during aging in long-lived giant mole-rats than in short-lived rats.
Sahm A, Bens M, Henning Y, Vole C, Groth M, Schwab M, Hoffmann S, Platzer* M, Szafranski* K, Dammann* P
Aging (Albany NY) 2018, 10(12), 3938-56 * equal contribution - Long-lived rodents reveal signatures of positive selection in genes associated with lifespan.
Sahm A, Bens M, Szafranski K, Holtze S, Groth M, Görlach M, Calkhoven C, Müller C, Schwab M, Kraus J, Kestler HA, Cellerino A, Burda H, Hildebrandt T, Dammann P, Platzer M
PLoS Genet 2018, 14(3), e1007272 - Neuron-specific inactivation of Wt1 alters locomotion in mice and changes interneuron composition in the spinal cord
Schnerwitzki D, Perry S, Ivanova A, Viegas Caixeta F, Cramer P, Guenther S, Weber K, Tafreshiha A, Becker L, Vargas Panesso IL, Klopstock T, Hrabe de Angelis M, Schmidt M, Kullander K, Englert C
Life Science Alliance 2018, 1(4), e201800106 - Regulation of RNA Polymerase I Transcription in Development, Disease, and Aging.
Sharifi S, Bierhoff H
Annu Rev Biochem 2018, 87, 51-73
