Subarea 3: Genetics and Epigenetics of Aging
The focus of Subarea 3 is on genetic and epigenetic determinants of life- and health span as well as aging in fish, rodents and humans. This line of research builds on the expertise of the institute in comparative and functional genomics.
The research is defined by five focus areas:
- Comparative genomics in short- and long-lived models of aging,
- Genomic engineering in N. furzeri,
- Epigenetics of aging,
- Non-coding RNAs in aging, and
- Comparative transcriptomics of aging.
Research focus of Subarea 3.
To uncover causative factors for aging, comparative genomics in short- and long-lived model systems are applied. Functional genomics is used to identify novel pathways contribute to aging of an organism and to validate the functional relevance of genetic and epigenetic changes that occur during aging. Furthermore, genetic risk factors for aging-related diseases are identified and functionally tested. The future development of the Subarea aims to integrate changes in host-microbiota interactions during aging, and how these influ ence clonal mutation and epigenetic alterations through metabolites and other signals.
Publications
(since 2016)
2018
- Cell-based RNAi screening and high-content analysis in primary calvarian osteoblasts applied to identification of osteoblast differentiation regulators.
Ahmad M, Kroll T, Jakob J, Rauch A, Ploubidou A, Tuckermann J
Sci Rep 2018, 8(1), 14045 - Cell cycle-dependent and -independent telomere shortening accompanies murine brain aging.
Ain Q, Schmeer C, Penndorf D, Fischer M, Bondeva T, Förster M, Haenold R, Witte OW, Kretz A
Aging (Albany NY) 2018, 10(11), 3397-420 - Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly.
Aramillo Irizar P, Schäuble S, Esser D, Groth M, Frahm C, Priebe S, Baumgart M, Hartmann N, Marthandan S, Menzel U, Müller J, Schmidt S, Ast V, Caliebe A, König R, Krawczak M, Ristow M, Schuster S, Cellerino A, Diekmann S, Englert C, Hemmerich P, Sühnel J, Guthke R, Witte OW, Platzer M, Ruppin E, Kaleta C
Nat Commun 2018, 9(1), 327 - DNA methylation of the rat Nr3c1 promoter and Igf2/H19 imprinting control regions and alterations after prenatal dexamethason treatment.
Awazie OB
Dissertation 2018, Jena, Germany - Kidney regeneration in fish.
Bates T, Naumann U, Hoppe B, Englert C
Int J Dev Biol 2018, 62(6-7-8), 419-29 - Naked mole-rat transcriptome signatures of socially suppressed sexual maturation and links of reproduction to aging.
Bens* M, Szafranski* K, Holtze S, Sahm A, Groth M, Kestler HA, Hildebrandt** TB, Platzer** M
BMC Biol 2018, 16(1), 77 * equal contribution, ** co-senior authors - Moderate H-Ras activation decreases the health span in Costello syndrome mouse model : novel H-RasG12V - driven advanced aging phenotyp.
Chennappan S
Dissertation 2018, Jena, Germany - Temperature throws a developmental switch.
Englert C
Proc Natl Acad Sci U S A 2018, 115(50), 12553-5 - Cellular and epigenetic drivers of stem cell ageing.
Ermolaeva** M, Neri** F, Ori** A, Rudolph** KL
Nat Rev Mol Cell Biol 2018, 19(9), 594-610 ** co-corresponding authors - Integrative analysis of differentially expressed genes and miRNAs predicts complex T3-mediated protective circuits in a rat model of cardiac ischemia reperfusion.
Forini F, Nicolini G, Kusmic C, D'Aurizio R, Rizzo M, Baumgart M, Groth M, Doccini S, Iervasi G, Pitto L
Sci Rep 2018, 8(1), 13870
